Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415199 | Microbes and Infection | 2010 | 5 Pages |
Abstract
Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-γ ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-γ responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.
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Authors
Gabriela C. Olivera, Maria C. Albareda, Maria G. Alvarez, Ana M. De Rissio, Laura E. Fichera, Gretchen Cooley, Pedro Yachelini, Hugo A. Hrellac, Hilda Riboldi, Susana A. Laucella, Rick L. Tarleton, Miriam Postan,