Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415205 | Microbes and Infection | 2010 | 6 Pages |
Abstract
IL-13 is a cytokine known to play a role in several pulmonary diseases, including asthma and fibrosis. The role of IL-13 in the context of pulmonary changes induced by helminth infection is unclear. Rats experimentally infected with Strongyloides venezuelensis and treated with anti-IL-13 neutralizing antibody were used to evaluate the role of IL-13 on functional and inflammatory changes of host lungs, and on parasite control. S. venezuelensis-induced airway hyperreactivity was IL-13-independent, but IL-13 played an essential role in driving airway mucus production and eosinophil infiltration. IL-13 was important for the control of egg production but not establishment in the intestine.
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Authors
Caroline M. Ferreira, Ana T.M. Pereira, Rafael S. de Souza, Fernanda M. Coelho, Stephen Poole, Mauro M. Teixeira, Deborah Negrão-Corrêa,