| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3415243 | Microbes and Infection | 2008 | 5 Pages |
Abstract
Lipid formulations containing BCG strains Danish 1331 or Moreau (Rio de Janeiro) were trialled as oral vaccines in rodent models. In mice, oral-delivery of either strain resulted in BCG colonisation of the alimentary tract lymphatics and induction of gamma-interferon responses. In guinea pigs, both strains provided pulmonary protection against Mycobacterium tuberculosis aerosol challenge, as shown by significantly reduced bacterial loads and lung:body weight ratios. Lipid-formulated BCG provided superior protection against M. tuberculosis over unformulated orally-delivered BCG (Moreau), and equivalent protection to sub-cutaneous BCG (Danish) immunisation. Oral-delivery of lipid-formulated BCG may offer a practical alternative to parenteral-route BCG vaccination.
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Authors
Julia Vipond, Martin L. Cross, Matthew R. Lambeth, Simon Clark, Frank E. Aldwell, Ann Williams,