Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415285 | Microbes and Infection | 2010 | 5 Pages |
Abstract
In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension. A murine, BALB/c, intranasal model of pneumonic plague was used in conjunction with in vivo neutrophil ablation, using the GR-1 antibody. This treatment reduced neutrophil numbers without affecting other leukocyte numbers. Neutrophil ablated mice exhibited increased bacterial colonisation of the lung 24 h post infection. Furthermore, exposure of Y. pestis to human neutrophils resulted in a 5-fold reduction in the number of viable bacterial cells, whereas, PBMCs had no effect.
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Authors
Thomas R. Laws, Martin S. Davey, Richard W. Titball, Roman Lukaszewski,