Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415311 | Microbes and Infection | 2007 | 7 Pages |
Abstract
Type I interferon-α/β play an essential role in immunity to viruses. While interferon-β has been used as a model of a complex promoter, many of the signalling pathways leading to interferon-β gene expression remain controversial. Recent milestones include the discovery of Toll-like receptors and RNA helicases that signal via a novel kinase complex composed of IκB kinase-ι/ɛ or TANK binding kinase-1. This review provides a timely summary of this rapidly expanding field, focusing specifically on the various viral RNA binding molecules and their associated signalling pathways.
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Authors
Michael R. Edwards, Louise Slater, Sebastian L. Johnston,