Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415651 | Microbes and Infection | 2009 | 7 Pages |
Abstract
TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways.
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Authors
Jie Wang, Yu Hu, Wei Wen Deng, Bing Sun,