Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415741 | Microbes and Infection | 2007 | 8 Pages |
Abstract
Lipoprotein e (P4) of Haemophilus influenzae is a phosphomonoesterase, encoded by the hel gene, that has been implicated in the acquisition of heme by this fastidious organism. However, lipoprotein e (P4) is also involved in the utilization of NAD and NMN. Some reports have concluded that the reported heme-related growth defect actually reflects a growth defect for NAD. In the current study, hel insertion mutants were constructed and a role for e (P4) in heme acquisition was demonstrated independent of its role in NAD or NMN acquisition. In addition, a rat model of infection demonstrated a role for e (P4) in the pathogenesis of invasive disease.
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Authors
Daniel J. Morton, Ann Smith, Timothy M. VanWagoner, Thomas W. Seale, Paul W. Whitby, Terrence L. Stull,