Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415893 | Microbes and Infection | 2007 | 7 Pages |
Abstract
GB virus B (GBV-B) infection of New World monkeys is considered to be a useful surrogate model for hepatitis C virus (HCV) infection. GBV-B replicates in the liver and induces acute resolving hepatitis but little is known whether the other organs could be permissive for the virus. We investigated the viral tropism of GBV-B in tamarins in the acute stage of viral infection and found that the viral genomic RNA could be detected in a variety of tissues. Notably, a GBV-B-infected tamarin with marked acute viremia scarcely showed a sign of hepatitis, due to preferential infection in lymphoid tissues such as lymph nodes and spleen. These results indicate that GBV-B as well as HCV is a pleiotropic virus in vivo.
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Authors
Koji Ishii, Sayuki Iijima, Nobuyuki Kimura, Young-Jung Lee, Naohide Ageyama, Shintaro Yagi, Kenjiro Yamaguchi, Noboru Maki, Ken-ichi Mori, Sayaka Yoshizaki, Sanae Machida, Tetsuro Suzuki, Naoko Iwata, Tetsutaro Sata, Keiji Terao, Tatsuo Miyamura,