Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3416077 | Microbes and Infection | 2006 | 10 Pages |
Abstract
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Teruyuki Hayakawa, Atsushi Matsuzawa, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo,