Article ID Journal Published Year Pages File Type
3416086 Microbes and Infection 2006 7 Pages PDF
Abstract

Interleukin (IL)-12/IL-23 signal transduction-deficient individuals with genetic defects in IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here we discuss recent questions that have arisen from clinical observations that cast doubt on the necessity of IL-12/IL-23 signaling in controlling infections with intracellular bacteria. Alternative IL-12/IL-23-dependent, interferon-γ-independent pathways of immunity to intracellular bacteria are also discussed.

Related Topics
Life Sciences Immunology and Microbiology Immunology
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