| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3416137 | Microbes and Infection | 2007 | 7 Pages |
Abstract
Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. Inbred mice and two species of non-human primates proved to be susceptible to experimental infection with PhHV-2. The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Byron E. Martina, Georges M.G.M. Verjans, Thijs Kuiken, Geert van Amerongen, Albert D.M.E. Osterhaus,