| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3417909 | Parasitology International | 2012 | 6 Pages |
Together with host and environmental factors, the systematics and population genetic variation of Opisthorchis viverrini may contribute to recorded local and regional differences in epidemiology and host morbidity in opisthorchiasis and cholangiocarcinoma (CCA). In this review, we address recent findings that O. viverrini comprises a species complex with varying degrees of population genetic variation which are associated with specific river wetland systems within Thailand as well as the Lao PDR. Having an accurate understanding of systematics is a prerequisite for a meaningful assessment of the population structure of each species within the O. viverrini complex in nature, as well as a better understanding of the magnitude of genetic variation that occurs within different species of hosts in its life cycle. Whether specific genotypes are related to habitat type(s) and/or specific intermediate host species are discussed based on current available data. Most importantly, we focus on whether there is a correlation between incidence of CCA and genotype(s) of O. viverrini. This will provide a solid basis for further comprehensive investigations of the role of genetic variation within each species of O. viverrini sensu lato in human epidemiology and genotype related morbidity as well as co-evolution of parasites with primary and secondary intermediate species of host.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Currently 2 cryptic species and 6 genetically distinct groups of O.viverrini occur in Thailand and Lao PDR. ► Review of recent data on molecular and enzyme markers indicated that population of O. viverrini are sub structured. ► Genetic variation within each species of O. viverrini complex plays roles in human epidemiology and pathology.
