Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3418049 | Parasitology International | 2007 | 5 Pages |
Abstract
The bacterial endosymbiont Wolbachia of several species of filarial nematodes plays an important role in the inflammatory pathology of filariasis. Nitric oxide (NO) production has also been implicated in the immune response during filarial infections. Here we present data indicating that a recombinant Wolbachia surface protein (rWSP) induces iNOs mRNA expression and NO production, as well as IFN-γ and a Th1-type antibody response, in inoculated BALB/c mice. This effect is not observed when mice are inoculated with a recombinant heat shock protein from Wolbachia (GroEL).
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Immunology and Microbiology
Parasitology
Authors
R. Morchón, C. Bazzocchi, J. López-Belmonte, J.R. Martín-Pacho, L.H. Kramer, G. Grandi, F. Simón,