| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3421454 | Transactions of the Royal Society of Tropical Medicine and Hygiene | 2008 | 5 Pages |
Abstract
SummaryCurrent diagnosis of schistosomiasis is still not ideal. In the present study we evaluated a targeted affinity approach using mAb 114-4D12, reactive with a unique Schistosoma mansoni-specific glycan epitope, combined with matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry. For nine of 11 urine samples (1 ml) from Egyptian individuals with different intensities of infection, a characteristic MALDI-TOF mass spectrum was observed, representing a series of fuco-oligosaccharides that are produced by schistosome eggs. The identification of these small molecule markers may lead to a new egg-load-related assay for light infections in schistosomiasis.
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Authors
Marjolein L.M. Robijn, Joost Planken, Dieuwke Kornelis, Cornelis H. Hokke, André M. Deelder,