Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3423453 | Trends in Parasitology | 2008 | 4 Pages |
Abstract
The apicomplexan pathogen Cryptosporidium parvum poses major logistical problems in the search for effective drug treatments. These treatments are required urgently because this parasite can cause severe disease and death in immunocompromised individuals and young children. In a recent study, the dependence of Cryptosporidium parasites on a single salvage pathway that leads to essential purine derivatives has been exploited and inhibitors have been identified that selectively target a key enzyme in this salvage process, inosine 5′-monophosphate dehydrogenase.
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Authors
John E. Hyde,