Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3423672 | Trends in Parasitology | 2009 | 4 Pages |
Abstract
Two recent papers published in Immunity and Cell Host & Microbe underline the great importance of B cells and of antibodies (Abs) in orchestrating crucial T helper cell type 2 (Th2) protective immune responses to gastrointestinal nematodes. The findings in animal models now raise major questions as to how B cells and Abs carry out these functions in humans. Here we discuss recent technological advances in humanizing animal models at the level of both Abs and their Fc-receptors, that might provide some answers.
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Richard J. Pleass, Jerzy M. Behnke,