Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3423682 | Trends in Parasitology | 2008 | 4 Pages |
Abstract
A new mathematical model developed by Lythgoe et al. shows that the semi-predictable order of trypanosome antigenic variation can be generated by two parasite-intrinsic factors. The first is the different probabilities of antigen-gene activation that result from the different molecular mechanisms by which the genes become expressed. The second is the density-dependent differentiation of slender to stumpy cells. The study has important implications for understanding the dynamics of antigenic variation and for modelling the consequences of therapeutic strategies directed against trypanosomes.
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Authors
Paula MacGregor, Keith R. Matthews,