Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3423683 | Trends in Parasitology | 2008 | 4 Pages |
Abstract
In a recent study, SM1-transgenic Anopheles stephensi, which are resistant partially to Plasmodium berghei, had higher fitness than non-transgenic mosquitoes when they were maintained on Plasmodium-infected blood. This result should be interpreted cautiously with respect to malaria control using transgenic mosquitoes because, despite the evolutionary advantage conferred by the transgene, a concomitant cost prevents it from invading the entire population. Indeed, for the spread of a resistance transgene in a natural situation, the transgene's fitness cost and the efficacy of the gene drive will be more crucial than any evolutionary advantage.
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Authors
Louis Lambrechts, Jacob C. Koella, Christophe Boëte,