Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3423971 | Trends in Parasitology | 2007 | 8 Pages |
Abstract
Over 40 cell lines are currently available from 13 ixodid and one argasid tick species. The successful isolation and propagation of several economically important tick-borne pathogens in tick cell lines has created a useful model to study interactions between tick cells and these viral and bacterial disease agents. Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host–vector–pathogen relationship. With the availability of genomics tools, tick cell lines will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine.
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Authors
Lesley Bell-Sakyi, Erich Zweygarth, Edmour F. Blouin, Ernest A. Gould, Frans Jongejan,