Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3423983 | Trends in Parasitology | 2007 | 8 Pages |
Abstract
Recent studies have shown that both Leishmania and HIV type-1 (HIV-1) hijack dendritic cell (DC) functions to escape immune surveillance using an array of elaborate strategies. Leishmania has developed a variety of adaptations to disrupt cellular defense mechanisms, whereas HIV-1 targets DCs to achieve a more efficient dissemination. The capacity of Leishmania and HIV-1 to target DCs through a common cell-surface molecule, namely DC-SIGN (dendritic cell specific ICAM-3-grabbing non-integrin), points to a possible dangerous liaison between these two pathogens. This review explores our knowledge of how Leishmania and HIV-1 interact dynamically with DCs, and how they exploit this cell type for their reciprocal benefit.
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Ravendra Garg, Nathalie Trudel, Michel J. Tremblay,