Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3424008 | Trends in Parasitology | 2006 | 7 Pages |
Abstract
Much of the epidemiology of Plasmodium falciparum in Sub-Saharan Africa focuses on the prevalence patterns of asexual parasites in people of different ages, whereas the gametocytes that propagate the disease are often neglected. One expected benefit of the widespread introduction of artemisinin-based combination therapy for malaria is a reduction in gametocyte carriage. However, the factors that affect the transmission of parasites from humans to mosquitoes show complex dynamics in relation to the intensity and seasonality of malaria transmission, and thus such benefits might not be automatic. Here, we review data on gametocyte carriage in the context of the development of naturally acquired immunity and population infectivity.
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Chris Drakeley, Colin Sutherland, J. Teun Bousema, Robert W. Sauerwein, Geoffrey A.T. Targett,