Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3424217 | Virology | 2013 | 4 Pages |
Abstract
MicroRNAs upregulated during CD4+ T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4+ T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.
► We found that miR-132 is highly upregulated upon CD4+ T cell activation. ► miR-132 potentiates HIV-1 replication in Jurkat cells. ► This is the first identification of a miRNA that enhances HIV-1 replication.
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Authors
Karen Chiang, Hongbing Liu, Andrew P. Rice,