| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3425680 | Virology | 2010 | 5 Pages |
Abstract
We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region.
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Authors
Yue Li, Rie Uenishi, Saiki Hase, Huanan Liao, Xiao-Jie Li, Takayo Tsuchiura, Kok Keng Tee, Oliver G. Pybus, Yutaka Takebe,