Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3425721 | Virology | 2008 | 5 Pages |
Abstract
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11 SIVmac251-infected pigtail macaques. Depletion of CD28+CD95+ central memory CD4+ T cells, but not other populations, correlated with both SIV viral load and disease progression. A low pre-infection level of central memory CD4+ T cells was also predictive of rapid disease progression. If confirmed in larger studies, our results suggest stratifying macaques for baseline central memory CD4+ T cells would be useful in defining both the pathogenesis of SIV disease and SIV vaccine efficacy.
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Authors
Rosemarie D. Mason, Robert De Rose, Nabila Seddiki, Anthony D. Kelleher, Stephen J. Kent,