Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3425858 | Virology | 2008 | 5 Pages |
Abstract
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
Keywords
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Virology
Authors
Laura Sironi, John L. Williams, Ana M. Moreno-Martin, Paola Ramelli, Alessandra Stella, Han Jianlin, Steffen Weigend, Guerino Lombardi, Paolo Cordioli, Paola Mariani,