Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3426113 | Virology | 2008 | 5 Pages |
Abstract
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.
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Authors
Yi Liu, Marcel E. Curlin, Kurt Diem, Hong Zhao, Ananta K. Ghosh, Haiying Zhu, Amanda S. Woodward, Janine Maenza, Claire E. Stevens, Joanne Stekler, Ann C. Collier, Indira Genowati, Wenjie Deng, Rafael Zioni, Lawrence Corey, Tuofu Zhu, James I. Mullins,