Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3426691 | Virology | 2009 | 5 Pages |
Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by JC virus (JCV) for which there is no cure. PML patients who have JCV-specific CD8+ cytotoxic T lymphocytes (CTL) in their blood have a better clinical outcome. We compared JCV-specific CTL responses in vitro elicited either by JCV peptide-loaded dendritic cells (DC) or by direct peptide stimulation of lymphocytes from 20 HLA-A⁎0201+ healthy controls, HIV+ and PML patients. JCV peptide-loaded DC elicited a stronger CTL expansion in 13/15 responders. DC can induce a potent JCV-specific CTL response in vitro, and may constitute a promising approach for PML immunotherapy.
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Authors
Angela Marzocchetti, Marco Lima, Troy Tompkins, Daniel.G. Kavanagh, Rajesh T. Gandhi, David W. O'Neill, Nina Bhardwaj, Igor J. Koralnik,