Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3426797 | Virology | 2008 | 7 Pages |
Abstract
Lipid rafts have been proposed as sites for the assembly of a number of viruses and are considered to play a major role in pseudotyping events. As a consequence, host glycosylphosphatidylinositol (GPI) anchored proteins commonly associated with lipid rafts can be found being incorporated into viral lipid envelopes with beneficial consequences for viral replication. In this review we will look at the link between lipid rafts, GPI-anchored proteins and retroviral particles and how these relationships can be exploited for the modification of enveloped viruses.
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Authors
Christoph Metzner, Brian Salmons, Walter H. Günzburg, John A. Dangerfield,