Prevention and control of highly pathogenic avian influenza with particular reference to H5N1

•Avian influenza H5N1 still remains a threat to public health and poultry industry.•Available control measures should be applied in a concerted strategy.•Biosecurity can be difficult to sustain in countries with limited resources.•Vaccines and vaccination can limit economic losses and virus circulation.•Vaccine and vaccination can contribute to virus endemicity if not properly managed.

Highly pathogenic avian influenza viruses of the H5N1 subtype emerged in Far East Asia in 1996 and spread in three continents in a period of 10 or less years. Before this event, avian influenza infections caused by highly pathogenic viruses had occurred in many different countries, causing minor or major outbreaks, and had always been eradicated.The unique features of these H5N1 viruses combined to the geographic characteristics of the area of emergence, including animal husbandry practices, has caused this subtype to become endemic in several Asian countries, as well as in Egypt. Our aim is to review the direct and indirect control strategies with the rationale for use, advantages and shortcomings – particularly resulting from practicalities linked to field application and economic constraints. Certainly, in low income countries which have applied vaccination, this has resulted in a failure to eradicate the infection. Although the number of infected countries has dropped from over 40 (2006) to under 10 (2012), the extensive circulation of H5N1 in areas with high poultry density still represents a risk for public and animal health.