| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3428565 | Virus Research | 2013 | 9 Pages |
Abstract
⺠We characterized infection-enhancing activity of IgG monoclonal antibodies (MAbs) against measles virus (MV) H protein. ⺠Partially neutralizing MAb CL55 enhanced MV infection in Fc receptor-expressing microglial cells. ⺠Strongly neutralizing MAb 20H6 enhanced MV infectivity in microglial cells only at sub-protective titers. ⺠At relevant protective titers, MAb 20H6 had a dominant blocking effect against antibody-enhanced MV infection. ⺠The antibody neutralization capacity determined the balance between protection and IgG-enhanced MV infectivity.
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Authors
Ianko D. Iankov, Alan R. Penheiter, Guy E. Griesmann, Stephanie K. Carlson, Mark J. Federspiel, Evanthia Galanis,