Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3429124 | Virus Research | 2010 | 6 Pages |
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) infects fully differentiated cells of the monocyte/macrophage lineage. Recently, CD163 was shown to be a cellular receptor capable of mediating infection of otherwise PRRSV non-permissive cell lines. CD163 is a macrophage differentiation antigen belonging to the scavenger receptor cysteine-rich (SRCR) family of membrane proteins. We provide a brief review of current knowledge regarding CD163 in relation to PRRSV infection, and propose a structure-based prediction of amino acid sequences involved in PRRSV interaction.
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Authors
Siao-Kun W. Welch, Jay G. Calvert,