Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3429234 | Virus Research | 2010 | 8 Pages |
Abstract
Hantaviral N and Gn proteins were shown to interact, thus providing the long-awaited evidence for one of the crucial steps in the virus replication at which RNPs are directed to the site of the virus assembly. Using pull-down assay and point mutagenesis it was demonstrated that intact, properly folded zinc fingers in the Gn protein cytoplasmic tail as well as the middle domain of the N protein (that includes aa residues 80–248) are essential for the interaction.
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Authors
Hao Wang, Agne Alminaite, Antti Vaheri, Alexander Plyusnin,