Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3430423 | Virus Research | 2008 | 4 Pages |
Abstract
Here, the antigenic specificity of the recombinant fusion proteins containing aa 286–426 of the dengue envelope protein fused to P64k from Neisseria meningitidis and the cross-reactive antibody response induced in immunized mice and monkeys were evaluated. The anti-dengue mice antibodies showed a higher reactivity to the homologous recombinant proteins compared to the wide cross-reactivity observed by dot blot to the viral antigens. The immune response induced by the recombinant proteins in mice and monkeys, was highly serotype specific. The serotype-specificity associated with these recombinant proteins in addition to the high antigenicity, immunogenicity and protecting capacity suggest their advantages as possible vaccine candidates.
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Authors
Alienys Izquierdo, Lidice Bernardo, Jorge Martin, Emidalys Santana, Lisset Hermida, Gerardo Guillén, María G. Guzmán,