Article ID Journal Published Year Pages File Type
3430691 Virus Research 2007 9 Pages PDF
Abstract

In 2003 an outbreak of sudden deaths occurred in 3–4-week-old piglets on a farm in New South Wales, Australia. There was a marked increase in the birth of stillborn foetuses. Pathological changes consisted of a multifocal non-suppurative myocarditis. A viral infection was suspected but a wide range of known agents were excluded. A modified sequence independent single primer amplification (SISPA) method was used to identify a novel virus associated with this outbreak. Conserved 5′UTR motifs, the presence of a putative Npro coding region and limited antigenic cross-reactivity with other members of the Pestivirus genus, support the placement of this virus in the Pestivirus genus. Phylogenetic analysis of the 5′UTR, Npro and E2 coding regions showed this virus to be the most divergent pestivirus identified to date.

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Life Sciences Immunology and Microbiology Virology
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