Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3432151 | American Journal of Obstetrics and Gynecology | 2016 | 89 Pages |
Abstract
Characterization of whole transcriptome gene expression revealed glucocorticoid-mediated regulation of corticotropin-releasing hormone and surfactant protein B via Erk3-independent and -dependent mechanisms, respectively. We demonstrated for the first time the expression and temporal regulation of corticotropin-releasing hormone protein in midtrimester human fetal lung. This unique model allows the effects of corticosteroids on fetal pulmonary morphologic condition to be distinguished from functional gene pathway regulation. These findings implicate Erk3 as a potentially important molecular mediator of antenatal glucocorticoid action in promoting surfactant protein production in the preterm neonatal lung and expanding our understanding of key mechanisms of clinical therapy to improve neonatal survival.
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Authors
Braden K. BS, R. Alan PhD, Elena MS, PhD, Milenka Cuevas MD, Cynthia MS, Rui PhD, Sylvain PhD, Kjersti MD, PhD,