Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3432382 | American Journal of Obstetrics and Gynecology | 2016 | 6 Pages |
Abstract
For primary population screening, cfDNA provides lower DR than sequential screening if considering detection of all chromosomal abnormalities. Assuming that no results cfDNA cases are high-risk improves cfDNA detection but with a greater FPR. cfDNA should not be adopted as primary screening without further evaluation of the implications for detection of all chromosomal abnormalities and how to best evaluate no results cases.
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Authors
Mary E. MD, Rebecca J. MPH, Ronald J. MD, Miriam PhD, Laura L. PhD, Robert J. PhD,