Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3432891 | American Journal of Obstetrics and Gynecology | 2015 | 11 Pages |
Abstract
We report for the first time that human trophoblast cells are highly sensitive to insulin regulation in early gestation. Maternal obesity associated with insulin resistance programs the placental transcriptome toward refractoriness to insulin with potential adverse consequences for placental structure and function.
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Authors
Luciana PhD, Maricela PhD, Patrick PhD, Subhabrata Basu, Judi Minium, Joanna BS, Mitchell MD, Patrick M. MD, Sylvie PhD,