Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3434242 | American Journal of Obstetrics and Gynecology | 2013 | 15 Pages |
Abstract
(1) Placental breast cancer resistance protein function is inhibited following even a short-term exposure to cannabidoil; (2) the ex vivo perfusion assay emphasize this effect by increased placental penetration of glyburide to the fetal compartment; and (3) these findings suggest that marijuana consumption enhances placental barrier permeability to xenobiotics and could endanger the developing fetus. Thus, the safety of drugs that are breast cancer resistance protein substrates is questionable during cannabis consumption by pregnant women.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Medicine and Dentistry (General)
Authors
Valeria MMedSc, Offer MD, Zvi PhD, Tamar MD, Boaz MD, Eyal MD, PhD, Gershon MD,