How to write and publish an original research article

Most physicians have had little or no exposure to systematic teaching or training during the medical school and residency with respect to writing and publishing an original research article. The framework of every article should include the study objective(s), study design, results, and conclusion(s). The current “Clinical Opinion” article proposes a set of guidelines, based on the authors' experience, which can be useful to junior physicians who plan to publish their work. These guidelines should assist not only in the writing process of the initial manuscript but also in responding to reviews and in modifying the original manuscript.