Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma

In uterine carcinosarcoma, estrogen receptor β expression is elevated and increases with disease progression, whereas estrogen receptor α and progesterone receptor are suppressed. Human epidermal growth factor receptor 2 expression is increased, whereas insulin-like growth factor receptor is lower than in normal endometrium. These data support a potential role for estrogen receptor β in disease progression via crosstalk with human epidermal growth factor receptor 2.