Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3437981 | American Journal of Obstetrics and Gynecology | 2008 | 7 Pages |
Abstract
The strong induction of IL-1β in BV-positive women appears to be associated with the production of the hydrolytic enzymes sialidase and prolidase by BV-associated bacteria. However, these 2 enzymes may inhibit the expected amplification of the proinflammatory IL-1β cascade as evaluated by the down-regulation of the IL-8/IL-1β ratio. A blunted response to IL-1β signals may cause the poor rise of neutrophils, which is peculiar to BV. This impairment of local defense may contribute to increased susceptibility to adverse outcomes in BV-positive pregnant women.
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Authors
Sabina PhD, Jennifer Flatow PhD, MPH, Manuela MS, Kelly MPH,