Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3441150 | American Journal of Obstetrics and Gynecology | 2008 | 11 Pages |
Abstract
In vitro maturation is an attractive strategy for IVF treatment; however, current IVM methods produce oocytes that perform poorly in the context of IVF. Data from the current study suggest that although IVM-MII oocytes closely resemble in vivo-MII oocytes for cellular pathways related to nuclear maturity, several pathways associated with cytoplasmic functions continue to be expressed in an immature manner. Additionally, IVM-MII oocytes have differences in the expression of genes related to cellular storage and homeostasis. Differentially expressed genes/pathways provide clues for the optimization of IVM techniques.
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Authors
Dagan PhD, Pasquale MD, MBE,