Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3441570 | American Journal of Obstetrics and Gynecology | 2008 | 7 Pages |
Abstract
Hyperglycemia in vitro induces yolk sac vasculopathy. Embryonic malformation is inversely correlated with the yolk sac vasculature development, suggesting that hyperglycemia-induced yolk sac vasculopathy may be one of the causative factors in hyperglycemia-induced embryonic malformation. Blockade of JNK1/2 activation restores hyperglycemia-induced vasculopathy and reduces the malformation rates. These findings indicate that JNK1/2 activation mediates the deleterious effect of hyperglycemia on yolk sac vasculature and embryonic development.
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Authors
Peixin PhD, Zhiyong PhD, E. Albert MD, PhD, MBA,