The Effect of Zaltoprofen on Physiotherapy for Limited Shoulder Movement in Breast Cancer Patients: A Single-Blinded Before-After Trial

Hase K, Kamisako M, Fujiwara T, Tsuji T, Liu M. The effect of zaltoprofen on physiotherapy for limited should movement in breast cancer patients: a single-blinded before-after trial.ObjectiveTo determine the efficacy of oral administration of zaltoprofen on shoulder range of motion (ROM) exercises for breast cancer patients after surgery.DesignSingle-blind, before-after trial.SettingRehabilitation facility in a Japanese university hospital.ParticipantsForty breast cancer patients (age range, 37−72y) with limited shoulder movement after surgery.InterventionSingle session of physiotherapy (PT) with or without oral administration of zaltoprofen.Main Outcome MeasuresActive shoulder ROM in flexion, abduction, and external rotation, as well as subjective pain score during shoulder movements.ResultsActive shoulder movements after ingesting a zaltoprofen tablet significantly improved in flexion, abduction (P<.001), and external rotation (P<.005). PT treatment improved flexion and abduction ROM in both the zaltoprofen and control groups and led to significantly larger flexion and abduction movements in the zaltoprofen group than in the control group (P<.01). There were no differences in pain scores between groups, but 2 patients who did not receive zaltoprofen complained of increased pain just after ROM exercises.ConclusionZaltoprofen taken orally before ROM exercises for painful shoulder after breast cancer surgery may enhance the effects of PT.