Anti-infertility significance of aqueous extract of I pomoea batatas (L.) Lam. against exposure of bisphenol A (BPA) promoted testicular toxicity in male Sprague Dawley rats

ObjectiveTo investigate the in vitro antioxidant activity of Ipomoea batatas (I. batatas) and anti-infertility efficacy of aqueous extract of I. batatas against Bisphenol A (BPA) induced testicular toxicity in experimental animals.MethodsThe experimental rats were divided into four groups and each group consisted of six animals. Group II – Bisphenol A diluted in propylene glycol at a dose of 200 mg/kg body weight was administered orally for 30 days. Reproductive toxicity encouraged animals illustrate notable alterations in the activites of hormones like FSH and LH and also in the levels of adenosine triphosphatase.ResultsThe hypo-osmotic swelling test display damaged sperm membrane integrity and histopathological examination of BPA intoxicated animals display a stuctural and functional alterations of reproductive organs that would interfere with its function and contribute to infertility.ConclusionAqueous extract of I. batatas at the concentration of 400 mg/kg body weight/day administered orally for 45 days prevent biochemical changes and structural alterations of testis and epididymis due to bisphenol A administration.