Cytoarchitectural variations in selected rat tissues following the administration of estradiol valerate in aged female rats

ObjectiveTo study the histomorphological changes with reference to estradiol valerate administration in aged female albino rats.MethodsThe observations showed in young, aged and aged administered with estradiol valerate (Progynova tablets) at the dose of 2 mg/day through oral gavages for one week. The histomorphological changes were observed in ovary, uterus, vagina and liver.ResultsEstradiol velerate administration improves the ovarian stroma and germinal epithelium. The vascular hyaline degeneration reduces. Vascular protective effects of estrogen are well established. The administration may be associated with endometrial hyperplasia and neoplasia. The stroma was comparatively less edematous with less active endometrial glands. The uteri exhibited endometrial epithelial cell pseudo stratification and hypertrophy. The vaginal histoarchitecture showed increased epithelial proliferation of the vaginal wall and improving thickening. Estradiol velerate does not showed any effect on liver architecture.ConclusionsThe administration of estradiol valerate showed its vascular protective effects. It does not showed any effect on liver architecture.