Anti-diabetes and anti-obesity: A meta-analysis of different compounds

Diabetes and obesity are chief health crisis and mainly age-related metabolic disorders. Diabetes is the main cause of morbidity and mortality worldwide. Obesity is linked with the progression of diabetes mellitus. High levels of glycerol, fatty acids, enzymes, pro-inflammatory markers and other obese entities build up insulin resistance in obese persons. The pathology of diabetes involves the dysfunction of β-islet cells of pancreas leading to deficient management of blood glucose level. This study demonstrates the anti-diabetic and anti-obesity effect of plant derived chemicals, some agonists, nutraceuticals, pharmaceutical drugs, some proteins and other compounds from 1998 to 2015. Plant derived from chemicals and other compounds were concluded to control diabetes and obesity by increasing number of glucose transporters, β-islet cells of pancreas, and lipid metabolism enzymes. In this way, the impairment of β-islet cells of pancreas is restored and the serum cholesterol and glucose levels of individuals are lowered. Further approaches are also needed to handle and cure diabetes and obesity.