Effect of Salmonella typhimurium infection on rat's cell oxidation and in vivo antioxidant activity of Vitellaria paradoxa and Ludwigia abyssinica aqueous extract

ObjectiveTo evaluate the effect of bacterial infection on cell oxidation and to study the in vitro and in vivo antioxidant activity of aqueous extract of Ludwigia abyssinica and Vitellaria paradoxa.MethodsThe Salmonella typhimurium-infected rats (1.5×108 CFU) concurrently received either different doses of plant extract (55, 110, 220 and 440 mg/kg) or ascorbic acid (vitamin C 100 mg/kg) daily for 18 d. The parameters like, lipid profile, reduced glutathione content, superoxide dismutase, catalase activities and bilirubin were assessed.ResultsInfection has resulted in an increase of heart reduced glutathione, heart and kidneys malondihaldehyde and liver superoxide dismutase activity followed by decreases of that of heart. The administration of the extract at 55, 110, 220 and 440 mg/kg body has resulted in the correction of some of these injuries.ConclusionsThe present study demonstrates that aqueous extract of Ludwigia abyssinica and Vitellaria paradoxa can fight against bacterial infection and cell oxidation induced by infection with Salmonella typhimurium.