Evaluation of antinociceptive, anti-inflammatory and anxiolytic activities of methanolic extract of Terminalia citrina leaves

ObjectiveTo investigate the antinociceptive, anti-inflammatory and anxiolytic effects of methanolic extracts of Terminalia citrina (T. citrina) leaves (Family: Combretaceae).MethodsThe antinociceptive activity was evaluated by acetic acid induced writhing method and radiant heat tail flick method while anti-inflammatory activity was evaluated by human red blood cell membrane stabilization method and anxiolytic activity by elevated plus maze model.ResultsThe methanolic extract of T. citrina leaves showed significant antinociceptive, anti-inflammatory and anxiolytic effects in dose dependent manner compared to their respective standard drugs.ConclusionsThe present study demonstrated that T. citrina possesses antinociceptive, anti-inflammatory and anxiolytic effects.