| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3454690 | Asian Pacific Journal of Tropical Disease | 2012 | 7 Pages |
ObjectiveTo evaluate the level of lipid-protein damage and antioxidant status in red blood corpuscle (RBC) and serum of healthy individuals to correlate between oxidative damage with the aging process.MethodsTwenty healthy individuals of each age group (11–20; 21–30; 31–40; 41–50; and 51–60 years old) were selected randomly. Blood samples were drawn by medical practitioner and serum was separated and RBC was isolated from blood samples. Malondialdehyde (MDA), protein carbonyls (PC) level were evaluated to determine the lipid and protein damage in RBC and serum. superoxide dismutase (SOD), catalase (CAT), glutathione and glutathione dependent enzymes were estimated to evaluate the antioxidant status in RBC and serum.ResultsIncreased MDA and PC levels strongly supported the increased oxidative damage in elderly subject than young subjects. The results indicated that, balance of oxidant and antioxidant systems in RBC and serum shifts in favor of accelerated oxidative damage during aging.ConclusionsOxidative stress in RBC and serum may particular interest in aging and may play important role in immunosenescence.
